Tue, 14/11/2017 - 14:15
,
Campus SB, E2 6, E.04

Prof. Dr. Carien Niessen
(
Host: Prof. Dr. Aránzazu del Campo, Jun.-Prof. Franziska Lautenschläger
)
University of Cologne

Making, maintaining and breaking epithelial barriers: the importance of integrating mechanical and chemical signals

Intercellular adhesion and cell polarity are crucial determinants of tissue architecture and morphogenesis. The Niessen lab asks how key regulators of cell and tissue architecture, such as intercellular junctions, polarity proteins and receptor tyrosine kinases, control the establishment and maintenance of self-renewing, multi-layered epithelia, such as the skin epidermis. How tissues link cell shape and position with cell fate essential for proper tissue function is not well understood. Using a combination of mouse genetics, high-resolution imaging and biophysical methods we explore at different length scales how cells integrate mechanical and chemical signals to build and maintain epithelial barriers. Our data indicate that feedback mechanisms between tension and signaling is essential for the formation of a functional epithelial barrier.

Upcoming Events

  • SFB 1027 Seminar

    Tue, 23/04/2024 - 14:00
    ,
    Campus SB, Building E2 6, Room E04

    Prof. Dr. Carsten Beta

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  • SFB 1027 Seminar

    Tue, 30/04/2024 - 14:00
    ,
    Campus SB, Building E2 6, Room E04

    Prof. Dr. Abdou Rachid Thiam

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  • SFB 1027 Seminar

    Tue, 28/05/2024 - 14:00
    ,
    Campus SB, Building E2 6, Room E04

    Prof. Dr. Sabine Klapp

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  • IRTG Intro Lecture

    Wed, 29/05/2024 - 14:00
    ,
    Campus SB, Building E2 9, Room 0.07

    Prof. Dr. Karin Jabobs

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  • IRTG Intro Lecture

    Tue, 11/06/2024 - 14:00
    ,
    Campus SB, Building E2 6, Room E.04

    Prof. Dr. Jochen Hub

    Everything You Always Wanted to Know About Molecular Dynamics Simulations* 

    (*But Were Afraid to Ask)

  • SFB 1027 summer camp

    Wed, 26/06/2024 - 09:00 to Fri, 28/06/2024 - 16:00
    ,
    BURG EBERNBURG 55583 Bad Kreuznach Bad Münster am Stein Ebernburg

 

 

 

 

 

 

 

 

 

 

 

 

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