Tue, 27/05/2014 - 14:15
,
Campus Homburg, Geb. 60, HS

Prof. Dr. Jan B. Parys
(
Host: Dr. Ivan Bogeski
)
Laboratory of Molecular and Cellular Signaling, Campus Gasthuisberg, Leuven

IP3 receptors and intracellular Ca2+ as regulators of cell fate

The inositol 1,4,5-trisphosphate (IP3) receptors form a family of ubiquitously expressed Ca2+-release channels of the endoplasmic reticulum. The complex spatio-temporal Ca2+ signals resulting from IP3 receptor activation in various physiological settings have been implicated in a plethora of cell functions. Since a number of years it became increasingly clear that the IP3 receptor is also involved in cell fate decisions. Depending on the presence of various regulatory proteins, including, but not limited to, Bcl-2 family members, Beclin 1, and protein kinase B, IP3 receptors can participate in both the regulation of apoptosis, a programmed cell death program, and of autophagy, a conserved degradation pathway, increasing cells survival after stress. The understanding of the exact mechanisms involved may in the future allow directing cell fate by modulating Ca2+ signalling in various pathological paradigms, including cancer and neurodegenerative diseases.

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    Everything You Always Wanted to Know About Molecular Dynamics Simulations* 

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