Tue, 22/07/2014 - 14:15
,
Campus Saarbr├╝cken, Geb. E2 6, Raum E04

Prof. Dr. Jian-Dong Huang
(
Host: Prof. Dr. Heiko Rieger
)
Department of Biochemistry, The University of Hong Kong

Synthetic Patterns: Sequential Establishment of Stripe Patterns in an Expanding Cell Population

Sequential and periodic patterns are recurring anatomical features in living organisms. Their rhythmic dynamics and intriguing beauty have fascinated generations of scientists. However, the understanding of the underlying mechanisms is hindered by the overwhelming molecular complexities in most cases. Engineered synthetic systems can simplify the complexities and refine the theoretical assumptions, thereby providing insights into the principles of naturally occurring phenomena. Here we described a synthetic pattern formation system by simply coupling cell density and motility, which enabled the programmed cells to form crisp, periodic stripes of high- and low- densities in a sequential and autonomous manner. Theoretical and experimental analyses revealed that the periodic structure arises from a recurrent aggregation process generated during the continuous expansion of the cell population. In accordance with our model prediction, patterns with different numbers of stripes were generated by tuning the activity of a single promoter. The results establish motility control as a simple, potent route for generating regular spatial structures without the need of a pacemaker, and illustrate the utility of synthetic genetic systems in studying pattern formation in spatially extended systems.

Upcoming Events

  • SFB 1027 Seminar

    Tue, 04/06/2024 - 14:15
    ,
    Campus SB, E2 6, E04

    Prof. Dr. Stefan Klumpp

    Physics in bacterial motility

  • SFB 1027 / INM - Seminar

    Wed, 05/06/2024 - 14:00
    ,
    Campus SB, D2 5, Leibniz Saal or online (Link below)

    Dr. Kevin Jahnke

    Engineering lipid membranes: From biophysical properties to biotechnological applications

  • IRTG Intro Lecture

    Tue, 11/06/2024 - 14:15
    ,
    Campus SB, Building E2 6, Room E.04

    Prof. Dr. Jochen Hub

    Everything You Always Wanted to Know About Molecular Dynamics Simulations* 

    (*But Were Afraid to Ask)

  • SFB 1027 Seminar

    Tue, 25/06/2024 - 14:15
    ,
    Campus SB, E2 6, E04

    Prof. Dr. Doris Heinrich

    t.b.a.

  • SFB 1027 summer camp

    Wed, 26/06/2024 - 09:00 to Fri, 28/06/2024 - 16:00
    ,
    BURG EBERNBURG 55583 Bad Kreuznach Bad M├╝nster am Stein Ebernburg

  • SFB 1027 Seminar

    Tue, 02/07/2024 - 14:15
    ,
    Campus SB, Building E2 6, Room E04

    Prof. Dr. Thomas Holstein

    t.b.a.

  • SFB 1027 Seminar

    Tue, 16/07/2024 - 14:15
    ,
    Campus SB, Building E2 6, Room E04

    Prof. Dr. Jona Kayser

    t.b.a.

 

 

 

 

 

 

 

 

 

 

 

 

  Legal notice Privacy policy