In active microrheology one monitors the response of a host medium to the presence of a tracer particle (TP), pulled through the medium by an external force F.  In non-equilibrium statistical mechanics, the same situation is modelled in a thought experiment in quest for the generalised fluctuation-dissipation relations. Recent MD studies of the anisotropic TP dynamics in liquids confined in 3D capillary-like geometries revealed an astonishingly violent response of the medium resulting in a super-diffusive broadening (SDB) of fluctuations of the TP position along the bias, which behaviour did not receive a convincing explanation so far. Via numerical simulations we demonstrated that the same SDB emerges in confined 2D stripe-like geometries, used in lab-on-chip devices, both for dense liquids and strikingly, also for granular fluids with non-elastic collisions. In this talk I will present a coherent theoretical description based on a “diffusive defect” picture which a) reproduces and explains the observed superdiffusive growth, b) shows that it is specific for confined geometries only, and is absent in unbounded 3D systems, and c) shows that it is a (quite extended in time for dense systems) transient regime, which paves the way to an ultimate diffusive behaviour with a giant diffusion coefficient, orders of magnitude larger than for F = 0 (passive microrheology). I will also demonstrate that this striking behavior occurs beyond the linear response regime and will extend our approach further to calculate the probability density function of the tracer in dense single-files, to establish velocity anomalies in confined systems and to describe the phenomenon of the negative differential mobility. Lastly, I will briefly overview dynamical behavior of interacting particles on comb-like structures.