Tue, 20/03/2018 - 14:15
,
Campus SB, E2 9, Room 0.07

Prof. Dr. Barbara Niemeyer
(
Host: Dr. Hendrik Hähl
)
Dpt. Biophysics, UdS (HOM)

Ca2+, immune cells and channelopathies

A wide variety of cellular functions depend on the spatial and temporal dynamics of intracellular Ca2+ signals. Especially for long lasting processes such as metabolism, gene expression, and cell proliferation, cells rely on the so-called store-operated Ca2+ entry pathway, which is particularly prominent in immune cells. Here, sensor proteins (STIM1, STIM2) located within the endoplasmic reticulum (ER) sense the Ca2+ concentration in the ER, and upon its depletion, cluster and trap Orai1 proteins into functional regions of the plasma membrane in close apposition to the ER. Highly selective Ca2+ channels are opened when the channel-activating domain of STIM proteins bind to the C-terminal of Orai1.

We will discuss the biological background, tools, methodologies and protocols to measure calcium fluxes and downstream effects.  Open questions that benefit from molecular modelling approaches will be discussed.

Upcoming Events

  • IRTG Intro Lecture

    Tue, 27/07/2021 - 14:15
    ,
    Online lecture via MS Teams

    Dr. Yvonne Schwarz

    Knowing when to talk or stay silent - how do secretory cells communicate with each other?”

    Investigating the molecular mechanisms of exocytosis using state-of-the-art microscopy, biochemistry, mouse genetics and electrophysiology

  • IRTG Intro Lecture

    Tue, 19/10/2021 - 14:15
    ,
    Online lecture via MS Teams

    Jun.-Prof. Laura Aradilla-Zapata

    t.b.a.

  • IRTG workshop

    Tue, 09/11/2021 - 09:00 to Wed, 10/11/2021 - 12:00
    ,
    t.b.a.

    Dr. Christiane Kasack

    Making it happen: Time and self management for your PhD

  • IRTG Intro Lecture

    Tue, 07/12/2021 - 14:15
    ,
    t.b.a.

    Prof. Dr. Sandra Iden

    t.b.a.

 

 

 

 

 

 

 

 

 

 

 

 

  Legal notice Privacy policy