Tue, 05/02/2019 - 14:15
,
Campus SB, Building E2 6, Room E04

Dr. Brandon Harvey
(
Host: Dr. Björn Becker
)
National Institute on Drug Abuse, Baltimore, USA

KDEL receptors are adaptive regulators of the endoplasmic reticulum proteome

Resident proteins of the endoplasmic reticulum (ER) lumen carry out many essential cellular functions including lipid metabolism, calcium storage, and protein synthesis and folding. Retention of ER-luminal proteins that are critical to these processes is regulated through their carboxy-terminal ER retention sequence (ERS), such as the canonical KDEL sequence in mammals. KDEL receptors reside in the cis-Golgi and retrogradely transport ERS-containing proteins that escape the ER lumen. The KDEL retrieval pathway has three known KDEL receptors which aid in the retrograde transport of ERS proteins from Golgi to the ER.  We found that under conditions of ER calcium deficiency, the KDEL receptors act as unfolded protein response (UPR) genes that are differentially upregulated by XBP-1 as an adaptive mechanism to counteract the efflux of ERS-containing proteins. Our observations that KDEL receptor expression is transcriptionally regulated by ER stress identifies the retrieval pathway as an adaptive response to minimize the loss of ER luminal proteins, particularly following the disruption of ER calcium homeostasis.  Lastly, we describe how augmentation of KDEL receptor expression may have therapeutic value in diseases associated with ER calcium deficiency.  Overall, we provide new insights into the KDEL retrieval pathway and its role in regulating ER proteostasis.

Upcoming Events

  • SFB 1027 Seminar

    Tue, 23/04/2024 - 14:00
    ,
    Campus SB, Building E2 6, Room E04

    Prof. Dr. Carsten Beta

    t.b.a.

  • SFB 1027 Seminar

    Tue, 30/04/2024 - 14:00
    ,
    Campus SB, Building E2 6, Room E04

    Prof. Dr. Abdou Rachid Thiam

    t.b.a.

  • SFB 1027 Seminar

    Tue, 28/05/2024 - 14:00
    ,
    Campus SB, Building E2 6, Room E04

    Prof. Dr. Sabine Klapp

    t.b.a.

  • IRTG Intro Lecture

    Wed, 29/05/2024 - 14:00
    ,
    Campus SB, Building E2 9, Room 0.07

    Prof. Dr. Karin Jabobs

    t.b.a.

  • IRTG Intro Lecture

    Tue, 11/06/2024 - 14:00
    ,
    Campus SB, Building E2 6, Room E.04

    Prof. Dr. Jochen Hub

    Everything You Always Wanted to Know About Molecular Dynamics Simulations* 

    (*But Were Afraid to Ask)

  • SFB 1027 summer camp

    Wed, 26/06/2024 - 09:00 to Fri, 28/06/2024 - 16:00
    ,
    BURG EBERNBURG 55583 Bad Kreuznach Bad Münster am Stein Ebernburg

 

 

 

 

 

 

 

 

 

 

 

 

  Legal notice Privacy policy