Tue, 03/09/2019 - 14:15
,
Campus SB, Building E2 6 Room E.04

Prof. Dr. Taher Saif
(
Host: Jun.-Prof. Franziska Lautenschläger
)
Mechanical Science and Engineering University of Illinois at Urbana-Champaign, USA

Neuronal tension – a new paradigm for understanding memory and learning

Memory and learning in animals are mediated by neurotransmitters that are released from vesicles clustered at the synapse. Vesicle clustering has been believed to result primarily from biochemical signaling processes that require the connectivity of the presynaptic terminal with the cell body, the central nervous system, and the postsynaptic cell. We show, using embryonic Drosophila motor neurons, that vesicle clustering at the neuromuscular presynaptic terminal depends on mechanical tension within the axons. Neurons generate this tension within the first two hours of synaptogenesis, and actively maintain the tension of about 1 nN by employing acto-myosin machinery. If the rest tension is perturbed mechanically, axons restore the rest tension either by relaxing or by contracting over a period of about 15 min. Vesicle clustering vanishes upon severing the axon from the cell body, but is restored when mechanical tension is applied to the severed end of the axon. Clustering increases when intact axons are stretched mechanically. We finally reveal the underlying mechanism by which tension and vesicle clustering are linked. The role of mechanical force in vesicle clustering is a new paradigm in the understanding of synaptic functions. This force paradigm may lead to new treatments for neurological diseases.

Upcoming Events

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    Tue, 27/07/2021 - 14:15
    ,
    Online lecture via MS Teams

    Dr. Yvonne Schwarz

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  • IRTG Intro Lecture

    Tue, 19/10/2021 - 14:15
    ,
    Online lecture via MS Teams

    Jun.-Prof. Laura Aradilla-Zapata

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  • IRTG workshop

    Tue, 09/11/2021 - 09:00 to Wed, 10/11/2021 - 12:00
    ,
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    Dr. Christiane Kasack

    Making it happen: Time and self management for your PhD

  • IRTG Intro Lecture

    Tue, 07/12/2021 - 14:15
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    Prof. Dr. Sandra Iden

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