Title | Fine-grained simulations of the microenvironment of vascularized tumours |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Fredrich, T., H. Rieger, R. Chignola, and E. Milotti |
Journal | Scientific Reports |
Volume | 9 |
Pagination | 11698 |
ISBN Number | 2045-2322 |
Abstract | One of many important features of the tumour microenvironment is that it is a place of active Darwinian selection where different tumour clones become adapted to the variety of ecological niches that make up the microenvironment. These evolutionary processes turn the microenvironment into a powerful source of tumour heterogeneity and contribute to the development of drug resistance in cancer. Here, we describe a computational tool to study the ecology of the microenvironment and report results about the ecology of the tumour microenvironment and its evolutionary dynamics. |
URL | https://doi.org/10.1038/s41598-019-48252-8 |
DOI | 10.1038/s41598-019-48252-8 |