TitleFine-grained simulations of the microenvironment of vascularized tumours
Publication TypeJournal Article
Year of Publication2019
AuthorsFredrich, T., H. Rieger, R. Chignola, and E. Milotti
JournalScientific Reports
Volume9
Pagination11698
ISBN Number2045-2322
Abstract

One of many important features of the tumour microenvironment is that it is a place of active Darwinian selection where different tumour clones become adapted to the variety of ecological niches that make up the microenvironment. These evolutionary processes turn the microenvironment into a powerful source of tumour heterogeneity and contribute to the development of drug resistance in cancer. Here, we describe a computational tool to study the ecology of the microenvironment and report results about the ecology of the tumour microenvironment and its evolutionary dynamics.

URLhttps://doi.org/10.1038/s41598-019-48252-8
DOI10.1038/s41598-019-48252-8