Tue, 22/10/2019 - 14:15
,
Campus Saarbrücken, E2 6, E04

Prof. Dr. Sandra Iden
(
Host: Prof. Dr. Heiko Rieger & Prof. Dr. Markus Hoth
)
Saarland University, Cell and Developmental Biology

Coordination of cell polarity, mechanics and fate - from molecular to organismal scale

Plasticity in cyto-architecture is essential for the formation and repair of complex tissues and for effective adaptation to organismal constraints. How changes in cell shape and intercellular communication are coordinated in continuously self-renewing tissues like the skin epidermis remains an intriguing open question. The Iden lab studies how cell polarity, cell adhesion and mechanical signals are coupled at the molecular, cellular and organismal level to ensure proper tissue function. Combining mouse genetics and disease models with primary co-culture systems, imaging and biophysical approaches, we aim to understand causal relationships between disturbed polarity signaling, degeneration, and cancer. In this context, our gain- and loss-of-function studies identified key roles of conserved polarity proteins and their interacting molecules in epithelial and non-epithelial cell types of the skin.

In this seminar, I will present recent mechanistic insights into coupling of polarity signaling with RhoA/actomyosin-dependent cell mechanics, putting forward a new paradigm how polarity networks safeguard epidermal cell fate decisions. Furthermore, our findings on intrinsic and extrinsic functions of apical polarity proteins in mammalian skin cancers and in tissue-scale communication between epithelial cells, melanocytes and immune cells will be summarized.

Upcoming Events

  • SFB 1027 Seminar

    Tue, 23/04/2024 - 14:00
    ,
    Campus SB, Building E2 6, Room E04

    Prof. Dr. Carsten Beta

    t.b.a.

  • SFB 1027 Seminar

    Tue, 30/04/2024 - 14:00
    ,
    Campus SB, Building E2 6, Room E04

    Prof. Dr. Abdou Rachid Thiam

    t.b.a.

  • SFB 1027 Seminar

    Tue, 28/05/2024 - 14:00
    ,
    Campus SB, Building E2 6, Room E04

    Prof. Dr. Sabine Klapp

    t.b.a.

  • IRTG Intro Lecture

    Wed, 29/05/2024 - 14:00
    ,
    Campus SB, Building E2 9, Room 0.07

    Prof. Dr. Karin Jabobs

    t.b.a.

  • IRTG Intro Lecture

    Tue, 11/06/2024 - 14:00
    ,
    Campus SB, Building E2 6, Room E.04

    Prof. Dr. Jochen Hub

    Everything You Always Wanted to Know About Molecular Dynamics Simulations* 

    (*But Were Afraid to Ask)

  • SFB 1027 summer camp

    Wed, 26/06/2024 - 09:00 to Fri, 28/06/2024 - 16:00
    ,
    BURG EBERNBURG 55583 Bad Kreuznach Bad Münster am Stein Ebernburg

 

 

 

 

 

 

 

 

 

 

 

 

  Legal notice Privacy policy