Immune killer cells, encompassing cytotoxic T lymphocytes (CTLs) from the adaptive immune system and natural killer (NK) cells from the innate immune system, play a pivotal role in eradicating pathogen-infected or tumorigenic cells. This intricate process hinges on two crucial factors: firstly, the application of efficient search strategies to pinpoint target cells, and secondly, the precise delivery of lethal blows to ensure the destruction of these target cells.

This lecture aims to provide a comprehensive overview of two fundamental aspects:

1. Intrinsic Killing Machinery: We will delve into the internal mechanisms employed by killer cells, which encompass the establishment of the immunological synapse, the intricate reorganization of the cellular cytoskeleton, and the processes involved in the enrichment and subsequent release of cytotoxic granules.
2. Migration and Search Strategies: Additionally, we will explore key regulatory factors that govern cell migration and the strategic search methods employed by killer cells in their quest to locate and neutralize target cells effectively.

Throughout the lecture, we will not only cover the theoretical foundations but also elaborate on the methodologies used to investigate these critical aspects, fostering a deeper understanding of the fascinating world of immune killer cell function.

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