Tue, 06/02/2024 - 14:00
,
Campus SB, Building E2 6, Room E04

Prof. Dr. Jan Steinkühler
(
Host: Dr. Philipp Hövel
)
Christian-Albrechts-Universität zu Kiel

Synthetic Cells to Advance Understanding of Biological Systems and Applications in Biotechnology

 

 

All living cells arise from pre-existing cells by division. Bottom-up synthetic biology aims to recreate living cells through construction, creating so-called synthetic cells. Recent advances in the controlled bottom-up assembly of synthetic cells have led to increasingly complex entities that we can use to learn about the physics of living systems or to exploit their functionality in engineering contexts. Along these lines, I will discuss three research topics: the cell-free expression and sorting of membrane proteins [1,2], force generation and remodeling of a tissue mimetic [3], and the ionic transport in nanofluidic lipid membrane channels.

[1] Steinkühler, J., Peruzzi, J. A., Krüger, A., Jacobs, M. L., Jewett, M. C., & Kamat, N. P. (2023). Improving cell-free expression of membrane proteins by tuning ribosome co-translational membrane association and nascent chain aggregation. bioRxiv, 2023-02.

[2] Peruzzi, J. A., Steinkuehler, J., Vu, T. Q., Gunnels, T. F., Lu, P., Baker, D., & Kamat, N. P. (2022). Hydrophobic mismatch drives self-organization of designer proteins into synthetic membranes. bioRxiv, 2022-06.

[3] Gu, A. A., Tran, P., Prindle, A., Kamat, N. P., & Steinkühler, J. (2023). Remodeling of lipid-foam prototissues by network-wide tension fluctuations induced by active particles. bioRxiv, 2023-06.

15:00 Coffee Break

15:15 PD Dr. Bin Qu (A2) Rapid and long-term T cell responses are distinctively regulated by mechanosensitive pathways

15:30 Dr. Carole Chevalier (A8, AG Santen) tau-island formation on the microtubule

Online Link: click here

Upcoming Events

  • SFB 1027 Seminar

    Tue, 12/11/2024 - 14:15
    ,
    Campus SB, Building E2 6, Room E04 or online via MS Teams

    Prof. Dr. Jamie Hobbs

    Using atomic force microscopy to understand the bacterial cell wall and its role in life, death, and antimicrobial resistance

  • SFB 1027 Seminar

    Tue, 19/11/2024 - 14:15
    ,
    Campus SB, Building E2 6, Room E04 or online via MS Teams

    Dr. Jona Kayser

    Drug Resistance Evolution as an Emergent Phenomenon in Heterogeneous Active Granular Matter

  • IRTG Intro Lecture

    Thu, 05/12/2024 - 14:00
    ,
    Campus SB, Building E2 9, Room 0.07 and online via MS Teams

    Prof. Dr. Bianca Schrul

    t.b.a.

  • SFB 1027 Seminar

    Tue, 10/12/2024 - 14:15
    ,
    Campus SB, Building E2 6, Room E04 or online via MS Teams

    Prof. Dr. Marco Fritzsche

    t.b.a.

 

 

 

 

 

 

 

 

 

 

 

 

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