A13 -

The role of MAPs in microtubule lattice dynamics

Principal Investigators: 

Microtubules are dynamic cytoskeletal filaments that grow and shrink by subunit addition or removal at their tips. In contrast to the tips, the microtubule lattice far from the tips was long considered to be static. The discovery of microtubule lattice dynamics by Aradilla Zapata and collaborators led to a paradigm shift and revealed a new dimension to microtubule dynamics. Based on recent studies, it is hypothesized that lattice dynamics are regulated by microtubule associated proteins (MAPs). A13 therefore plans to investigate the influence of MAPs on lattice dynamics. By gaining insight into this interplay, A13 expects to contribute to a refined understanding of microtubule function in cells.

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