This project aims to develop and investigate novel bioinspired strategies for the management of bacterial biofilm formation on oral surfaces. The main objective is to elucidate the process of initial bio-adhesion taking place in situ on the tooth as well as mucosal surface at the molecular level, and to modify the physiological pellicle layer by application of biomimetic apatite particles and plant extracts in order to control the subsequent adherence of oral bacteria and yeasts.