This project aims to develop and investigate novel bioinspired strategies for the management of intraoral biofilm formation. The main objective is to elucidate the process of initial bio-adhesion taking place on natural tooth surfaces at the molecular level, and to modify the physiological pellicle by combinations of biomimetic apatite particles, polyphenols and essential oils or by nano-carriers (casein micelles, lipid nanoparticles) loaded with plant extracts.