C4 -

Calcium-Redox feedback loop in immune cells: New players and regulatory mechanisms.


During inflammation, immune cells encounter environments rich in reactive oxygen species (ROS), generated by phagocytes. To further explore the interplay between two second messengers (Ca2+ and ROS) we want to 1) analyse the role of the Ca2+ channel Orai2 in the regulation of the oxidative burst and dissect the requirements of STIM-Orai2 interfaces in controlling Ca2+ and redox homeostasis. 2) Identify and characterize additional molecular players of the Ca2+- redox feedback loop and examine if and how these candidate channels are regulated by oxidative modifications themselves













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