C10 -

A kinetic proofreading mechanism for sensing lipid saturation

Principal Investigators: 

All organisms that cannot control their body temperature must adapt their membrane lipid composition to the ambient temperature, a phenomenon referred to as homeoviscous adaptation. It remains largely unknown how subtle changes of the membrane composition and properties can be sensed and amplified to control adaptation. C10(N) studies the mechanisms by which the lipid saturation sensor Mga2 amplifies signals from the membrane to upregulate the production of unsaturated lipids for adaptation. By a combination of theory, systematic molecular dynamics simulations, and quantitative biochemical reconstitution experiments C10(N) aims to uncover the physical basis of lipid saturation sensing.

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