A2 -

Dynamics of T cell polarization

Principal Investigators: 

T killer cells are polarized during migration and elimination of target cells. We will define killer cell search strategies in 2D and 3D environments. The main hypotheses are that killer cells work cooperatively to find target cells and that their search strategies are influenced by the microenvironment generated by other cells and metabolites like H2O2. Furthermore, we will analyze directed vesicle transport towards or away from the cytotoxic synapse. The concept of paired vesicle transport, which was established together with A3, will be tested for cytokine transport in cargo vesicles of killer cells involving different motor proteins.













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