A3 -

Physical processes during T cell activation, polarization and killing

Principal Investigators: 
Summary: 

Cytotoxic T lymphocytes and natural killer cells are the main cytotoxic killer cells of the human body to eliminate pathogen-infected or tumorigenic cells. Various processes are involved in a successful killing event: activation of the killer cell, migration and search for the target, formation of a synapse and polarization upon contact with the target, transport of cytotoxic agents towards the synapse, and finally elimination of the target via necrosis or apoptosis. In this project we address various theoretical aspects of the biophysics of killing in collaboration with projects A2, C4, and C7, ranging from intra-cellular and cellular random search processes, over different killing strategies inducing necrosis or apoptosis, to a mechanistic understanding of the molecular motor driven cytoskeleton rotation towards the synapse during polarization.

 

 

 

 

 

 

 

 

 

 

 

 

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