B6 -

Dynamics of ligands and forces in T cell activation

Principal Investigators: 

T cell activation and deactivation by Antigen Presenting Cells (APC) occur by a concerted action of membrane receptors spatially localized at the immunological synapse and mechanically coupled to active cytoskeletal structures. In this project, we will develop models of APCs that capture the dynamic interplay between mechanics and individual receptor complexes at the immunological synapse. As a unique feature, we will use phototriggers to dynamically tune the biochemical and mechanical parameters of the APC. In close cooperation with A2, we will image T cell response (Ca2+ levels, cytoskeletal dynamics or MTOC polarization) and force changes to the in situ variations of receptor density and engagement.













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