A8 -

Motor-driven transport of intracellular cargo: Cooperativity and control


In this project we address several aspects of the cooperative dynamics of molecular motors. We analyze, both experimentally and theoretically, the dynamics of rigid and vesicular cargo which is propelled by teams of dynein and kinesin motors along microtubules (MTs). The knowledge gained in this part of the project will be applied to identify possible strategies for external motility control in intracellular and artificial transport systems. We will focus on the influence of posttranslational modifications of MTs on the motor-dynamics, as well as on the mechanical properties of motor-driven MTs.













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