A8 -

Motor-driven Transport of Intracellular Cargo: Cooperativity and Control


In this project we will analyze cargo transport driven by teams of molecular motors in a combined experimental and theoretical approach. The cooperation of molecular motors and the response to varying external control parameters will be studied in in vitro motility assays. Using these setups we will characterize cargo transport by teams of kinesin-1 and cytoplasmic dynein motors (present at defined ratios) under well-controlled experimental conditions (e.g. temperature, viscosity, ATP concentration). The theoretical models will be used to characterize the contributions of individual motors in different kinds of motor-cargo complexes. Taken together, our results will allow us to develop models for bidirectional transport along microtubules on a larger scale.













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